diff --git a/src/jtag3.c b/src/jtag3.c
index e3e39fbe..3ca5f4e3 100644
--- a/src/jtag3.c
+++ b/src/jtag3.c
@@ -1504,6 +1504,30 @@ int jtag3_open_common(PROGRAMMER *pgm, const char *port) {
   }
 #endif
   if (rv < 0) {
+    // Check if SNAP or PICkit4 is in PIC mode
+    for(LNODEID ln=lfirst(pgm->id); ln; ln=lnext(ln)) {
+      if (matches(ldata(ln), "snap")) {
+        pinfo.usbinfo.vid = USB_VENDOR_MICROCHIP;
+        pinfo.usbinfo.pid = USB_DEVICE_SNAP_PIC_MODE;
+        int pic_mode = serial_open(port, pinfo, &pgm->fd);
+        if(pic_mode >= 0) {
+          msg_error("\n");
+          pmsg_error("MPLAB SNAP in PIC mode detected!\n");
+          imsg_error("Use MPLAB X or Microchip Studio to switch to AVR mode\n\n");
+          return -1;
+        }
+      } else if(matches(ldata(ln), "pickit4")) {
+        pinfo.usbinfo.vid = USB_VENDOR_MICROCHIP;
+        pinfo.usbinfo.pid = USB_DEVICE_PICKIT4_PIC_MODE;
+        int pic_mode = serial_open(port, pinfo, &pgm->fd);
+        if(pic_mode >= 0) {
+          msg_error("\n");
+          pmsg_error("PICkit4 in PIC mode detected!\n");
+          imsg_error("Use MPLAB X or Microchip Studio to switch to AVR mode\n\n");
+          return -1;
+        }
+      }
+    }
     pmsg_error("did not find any device matching VID 0x%04x and PID list: ",
       (unsigned) pinfo.usbinfo.vid);
     int notfirst = 0;